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Monday, September 5, 2011

Fwd: | 09.01.11 | Dairy JV nabs India's excipients maker Brahmar; Fareva buys Pfizer plant



-------- Original Message --------
Subject: | 09.01.11 | Dairy JV nabs India's excipients maker Brahmar; Fareva buys Pfizer plant
Date: Thu, 1 Sep 2011 10:49:52 -0400 (EDT)
From: FiercePharmaManufacturing <editors@fiercepharmamanufacturing.com>
Reply-To: editors@fiercepharmamanufacturing.com
To: nbrauchitsch@yahoo.com


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September 1, 2011

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Today's Top Stories:
1. Dairy JV nabs India's Brahmar
2. Fareva moves into U.S. with Pfizer plant buy
3. BASF raises excipient, API prices 10%
4. CMOs to lay off more than 100 in NY, Ireland
5. New Promega plant to add capacity

Spotlight:
Baxter pumps up lyophilization capacity at Halle plant

Also Noted:
Pharma packaging to be $62B market by 2015; Batavia, Xendo ink manufacturing, marketing deal; Much more...

News From The Fierce Network:
1. S&N takeover rumors rekindled
2. Facebook app shows how people swap germs
3. Beleaguered Xoma CEO Engle resigns


Capitalizing on the Outsourcing Option - New Fierce eBook

Risk areas for many biotechs and pharmas in today's changing market include lack of expertise and infrastructure. This eBook addresses recalibration challenges and strategies to capitalize using the contract development and manufacturing (CDMO) option. Download now.


Webinars

> Webinar: Active Directory & the Cloud for Biotech & Pharma Sept. 21, 2pm ET / 11am PT

Events

> PDA Europe: Pharmaceutical Cold Chain Management & Good Distribution Practice - 27-30 September 2011 - Berlin, Germany
> 2015 Readiness Workshop - September 28-29, and October 26-27, 2011 - Lawrenceville, NJ
> 9th Annual Cold Chain & Temperature Control Global Forum - September 26 -30, 2011 - Philadelphia, PA
> Partnership Opportunities in Drug Delivery - October 5-6, 2011 - Boston, MA
> BioProcess International Conference & Exhibition - Oct 31 - Nov 4 - Long Beach, CA
> 13th Annual Contract Manufacturing for Pharma & Biotech Companies - December 5-7, 2011 - Philadelphia, Pennsylvania

Marketplace

> Capitalizing on the Outsourcing Option - New Fierce eBook

Jobs

> Associate Director/Director - Translational Medicine - Nonclinical Safety Assessment - Regulus Therapeutics

New Fierce eBook: Between an Industry Rock and a Political Hard Place: The FDA's 510(k) Initiative

This FierceMedicalDevices eBook examines the background situation, current position and the future of the CDRH's revision of the 510(k) premarket notification process. Click here to download today.

Today's Top Stories

1. Dairy JV nabs India's Brahmar

By Tracy Staton Comment | Forward | Twitter | Facebook | LinkedIn

DMV-Fonterra Excipients (DFE), a joint venture pairing two large dairy groups, has struck a deal to acquire India's Brahmar Cellulose in a bid to become the primary go-to supplier of lactose excipients to pharma manufacturers around the globe.

Manufacturers in India and around the globe use these purified lactose excipients as a filler in tablets, capsules and powders for medical inhalers. And DFE says it accounts for about half of the global sales of lactose excipients and 5% to 10% of oral tablet excipients.

Dutch dairy company Royal FrieslandCampina and New Zealand dairy company Fonterra created the joint venture. They say the acquisition, completed for an undisclosed price, will make the JV the "sole manufacturer and supplier of the most commonly used diluents and superdisintegrants" needed by pharma manufacturers.

"Long-term synergies will be achieved by combining DFE's current global market position and sales network with Brahmar Cellulose
extensive product knowledge and market position in India," DFE CEO Jan Jongsma said. Taking out the competition should help shorten buyers' supply chains, but there's no word what it may do to their costs.

- see the DFE release
- get the story from in-PharmaTechnologist
- read the article from the Economic Times

Related Articles:
FDA: 5 recalls traced to excipients in 2010
FDA system would speed excipient screening

Read more about: excipients, DMV-Fonterra Excipients, India, Manufacturing Deals
back to top


2. Fareva moves into U.S. with Pfizer plant buy

By Tracy Staton Comment | Forward | Twitter | Facebook | LinkedIn

The big European contract manufacturer Fareva has now established a U.S. beachhead as it pursues plans to expand into the U.S. market. The pharma manufacturer has stepped in to buy one of Pfizer's ($PFE) manufacturing facilities in Virginia.

In the deal, the 500 Pfizer workers who make Advil, Chapstick and other products will now work for Fareva, which has an arrangement in place to spruce up the facility with a $42 million upgrade and add about 90 new jobs over 5 years.

Local economic development officials breathed an audible sigh of relief on the news. Pfizer had announced back in the spring of 2010 that it would shutter the plant as part of a big revamp planned for its manufacturing division. In acquiring the plant, Fareva also got the contract to continue supplying Pfizer.

"We have been looking for the right opportunity to expand our manufacturing footprint into North America and establish our pharmaceutical and cosmetics businesses in the United States," said Fareva CEO Bernard Fraisse. "The Henrico County site has a talented and motivated workforce and state-of-the-art manufacturing, packaging and warehousing facilities that are a perfect fit for growing our commercial portfolio in this region."

Based in Luxembourg, Fareva employs 5,500 and reported $1.2 billion in 2010 revenues. The company operates 28 manufacturing facilities in Europe and around the world.

- read the Henrico Citizen story

Related Articles:
Pfizer shows sustainability/cost balance at packaging plant
Pfizer plant prepped before demolition to contain killer API

Read more about: Pfizer, Manufacturing Plant, Fareva
back to top


3. BASF raises excipient, API prices 10%

By Tracy Staton Comment | Forward | Twitter | Facebook | LinkedIn

Germany's BASF plans a 10% price hike worldwide on pharmaceutical excipients and active pharmaceutical ingredients. The company blamed continued increases in costs for raw materials, energy and labor for the increase, which is the second 10% mark-up for BASF this year. Any existing price contracts remain in force.

The price hike covers BASF's entire portfolio of excipients, the company said in a statement, including binders such as Kollidon, coatings such as Kollicoat, and solubilization agents Cremphor and Lutrol. The generic APIs affected by the hike include commonly used ingredients like ibuprofen, caffeine and pseudoephedrine.

BASF has been economizing wherever it can, trying to remain competitive on price, spokesman Ralf Fink told in-Pharma Technologist. "However, the significant cost increases of the past quarters cannot be offset by any short-term measures," Fink said.

Acknowledging that price increases "are truly a burden to the overall industry," Fink wouldn't say whether he thought BASF's competitors would follow suit with their own prices. The BASF increases take effect today.

- see the release from BASF
- get more from in-Pharma Technologist

Related Article:
Raw material sourcing meets cGMP testing, distribution

Read more about: raw materials, API, excipients, BASF
back to top


4. CMOs to lay off more than 100 in NY, Ireland

By Tracy Staton Comment | Forward | Twitter | Facebook | LinkedIn

Two contract manufacturers plan triple-digit job cuts, with a combination of layoffs and voluntary buyouts. Contract Pharmaceuticals is winding down its Buffalo, NY, plant, purchased from Bristol-Myers Squibb ($BMY) in 2005. By the end of the year, another 128 workers will be laid off. Meanwhile, United Drug plans 150 job cuts at a plant in Ireland as part of a recently announced streamlining program.

In Buffalo, Contract plans two stages of layoffs. Forty-seven jobs will be cut at the end of November, and the remaining employees will be let go by year's end. As Outsourcing-Pharma points out, these cuts represent three-fourths of the plant's remaining 161 employees.

The Buffalo operations will be consolidated with a Contract plant in Ontario. At the time the Buffalo plant was slated for closure, 260 employees worked there. The company had bought the 415,000-square-foot plant from BMS thinking it could attract enough business to justify the expansion, but the faltering economy interfered with those plans, according to executives.

United Drug attributes its cuts to government decisions to cut healthcare spending. The CMO said austerity moves have significantly pinched sales, forcing it to shed jobs and make other streamlining moves; it announced plans to restructure earlier this month.

"We are embarking on a business transformation program in order to remain competitive in the market," a spokesperson told Outsourcing-Pharma. "Up to 150 full- and part-time staff may be impacted by the changes." The exact number of employees cut depends on the outcome of United Drug's voluntary redundancy program and on its ability to move staffers to posts elsewhere in the business.

- see the Outsourcing-Pharma news
- get more, also from Outsourcing-Pharma

Related Articles:
U.S. tax reform or not, offshore beckons
The other dark side of Merck's 13,000 layoffs
Cut jobs not likely to reappear

Read more about: Contract Manufacturer, layoffs, Contract Pharmaceuticals, United Drug
back to top


5. New Promega plant to add capacity

By Tracy Staton Comment | Forward | Twitter | Facebook | LinkedIn

Promega is building a new cGMP facility that will turn out FDA-regulated molecular biology products. The 260,000 square-foot plant will bring 100 people onto the company's payroll, Contract Pharma reports.

Based in Madison, WI, the company plans to use most of the new space for manufacturing, including fixed production lines and flexible manufacturing areas. The plant will help Promega grow, particularly in products for diagnostics makers, such as sample prep systems and reagents used in medical tests, the company said.

"Molecular biology opens doors not only to new understanding of life, but to practical applications that enhance the health of our citizens," CEO Bill Linton said in a statement. "This building is our next step in expanding our product supply capabilities worldwide."

Promega is using environmentally friendly construction practices in building the new facility. Geothermal heating and cooling, bio-retention stormwater ponds, and dark-sky compliant lighting are among them.

- read the release from Promega
- get more from Contract Pharma

Related Article:
CDI, Promega to collaborate on in vitro assays

Read more about: cGMP, Promega
back to top


Also Noted

Webinar: Active Directory & the Cloud for Biotech & Pharma
Sept. 21, 2pm ET / 11am PT

Biotech and pharmaceutical companies are leaders cloud/SaaS technology adoption. This webinar will discuss the pros and cons of extending Active Directory to Cloud/SaaS Apps for single sign-on and automated provisioning/de-provisioning. Register today.


TODAY'S SPOTLIGHT... Baxter pumps up lyophilization capacity at Halle plant

Baxter ($BAX) has once again expanded the freeze-drying capacity at its BioPharma Solutions contract manufacturing facility in Halle, Germany. Increased pharma demand for cytotoxic contract manufacturing prompted the investment, the company said. Report

> The pharmaceuticals packaging market is expected to hit $62 billion by 2015, according to a new study from Freedonia Group, with 70% of demand coming from U.S., Japan and Western Europe, but China, India and Brazil will grow quickly as well. Report

> Batavia Bioservices has inked a deal to take over Xendo's bioprocess manufacturing, and the two companies will team up on marketing efforts. Story

> EMD Millipore, a division of Merck KGaA, has agreed to buy Amnis, which makes high-speed cell imaging instrumentation for flow cytometry uses. News

> Vivalis increased first-half sales by 165% and cut its net loss after landing two new licensing agreements for its EB66 technology used in vaccine production. Story

> France's Roquette wrapped up a capital-investment plan at its Lestrem facility, which makes injectable carbohydrates for use in parenteral drug manufacturing. Piece

> Contract manufacturing in Brazil is set to grow quickly, especially the manufacturing of APIs, market research firm RNCOS says in a new report. Report

> The Consumer Healthcare Products Association lodged some criticisms of the FDA's draft guidance on nanotechnology, including the agency's definition of the term. Article

Webinars

> Webinar: Active Directory & the Cloud for Biotech & Pharma Sept. 21, 2pm ET / 11am PT

Biotech and pharmaceutical companies are leaders cloud/SaaS technology adoption. This webinar will discuss the pros and cons of extending Active Directory to Cloud/SaaS Apps for single sign-on and automated provisioning/de-provisioning. Register today.

Events

> PDA Europe: Pharmaceutical Cold Chain Management & Good Distribution Practice - 27-30 September 2011 - Berlin, Germany

PDA Europe: Pharmaceutical Cold Chain Management & Good Distribution Practice - Addresses Transportation Issues for the emerging Middle Eastern and African markets, featuring Guest Speakers from India. Conference, Exhibition, Training Course 

> 2015 Readiness Workshop - September 28-29, and October 26-27, 2011 - Lawrenceville, NJ

Learn business and technical aspects of tracking and tracing serialized product through the supply chain with GS1 Standards. Unique hands on training uses computerized simulation to explore different supply chain scenarios and help you get ready for 2015 pedigree. Register Now!

> 9th Annual Cold Chain & Temperature Control Global Forum - September 26 -30, 2011 - Philadelphia, PA

The 9th Annual Cold Chain & Temperature Control Global Forum will examine the modern cold chain - including all temperature range products and their regulatory requirements - as well as evolving sectors such as Medical Devices & Diagnostics, Generics, APIs, Clinical and Biologics and cell therapies. It is set to take place September 26 -30 in Philadelphia. See what else is new on the cold chain agenda here.

> Partnership Opportunities in Drug Delivery - October 5-6, 2011 - Boston, MA

Keynoted by Dr Robert Langer of MIT, this is a strategic level event for pharma and biotech BD&L executives to meet a wide range of drug delivery companies with the latest technologies. Fierce readers receive 15% off with code FBEL. Register or learn more: click here

> BioProcess International Conference & Exhibition - Oct 31 - Nov 4 - Long Beach, CA

BPI is your one stop industry resource for driving down costs, improving quality, achieving rapid, robust and resilient process development and manufacturing - and is the largest and most highly respected event solely dedicated to biopharmaceutical manufacturing. Learn more, view the agenda or download the brochure. You can even get sneak peek at the caliber of content by downloading presentations.

> 13th Annual Contract Manufacturing for Pharma & Biotech Companies - December 5-7, 2011 - Philadelphia, Pennsylvania

This conference will be taking an in-depth look at the future of strategic CMO outsourcing, assessing risk management of quality systems, audit process to ensure GMP, and tools to expedite your supply chain process, amongst other things within the pharma and biologics outsourcing field. Learn more.

Marketplace

> Capitalizing on the Outsourcing Option - New Fierce eBook

Risk areas for many biotechs and pharmas in today's changing market include lack of expertise and infrastructure. This eBook addresses recalibration challenges and strategies to capitalize using the contract development and manufacturing (CDMO) option. Download now.

Jobs

> Associate Director/Director - Translational Medicine - Nonclinical Safety Assessment - Regulus Therapeutics

Regulus Therapeutics Inc. is a biopharmaceutical company leading the discovery and development of innovative new medicines based on microRNAs. Regulus seeks a motivated 6 plus years of drug development experience to join our efforts in translating microRNA biology into human therapeutics. The position requires proven ability to work in a fast-paced biotech environment. Read more.


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